A systematic review of the association of obesity with the outcomes of inflammatory rheumatic diseases.

Journal Article (Journal Article;Systematic Review)

This was a systematic review of the literature on the association between obesity and the outcome of inflammatory rheumatic diseases. We conducted a literature search using PubMed®, Embase and PsycINFO®. Articles were classified into three categories based on the effects of obesity on the outcomes of inflammatory rheumatic diseases. The subject population, country, type of studies, number of patients, measurement of obesity and outcomes assessed were presented. Quality was appraised using Kmet et al's criteria. 4,331 articles were screened and 60 were relevant to the objective. Obesity had a negative, positive and neutral association with outcomes of inflammatory rheumatic diseases in 38 (63.3%) studies with 57,612 subjects, 11 (18.3%) studies with 3,866 subjects, and 11 (18.3%) studies with 3,834 subjects, respectively. In most studies, the disease population had been diagnosed with rheumatoid arthritis (RA). Tumour necrosis factor-α inhibitors were mostly associated with negative outcomes. More studies examining subjects outside Europe and North America and diseases other than RA are warranted.

Full Text

Duke Authors

Cited Authors

  • Lee, YX; Kwan, YH; Lim, KK; Tan, CS; Lui, NL; Phang, JK; Chew, EH; Ostbye, T; Thumboo, J; Fong, W

Published Date

  • June 2019

Published In

  • Singapore Med J

Volume / Issue

  • 60 / 6

Start / End Page

  • 270 - 280

PubMed ID

  • 31243460

Pubmed Central ID

  • PMC6595055

Electronic International Standard Serial Number (EISSN)

  • 2737-5935

Digital Object Identifier (DOI)

  • 10.11622/smedj.2019057


  • eng

Conference Location

  • India