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Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey.

Publication ,  Journal Article
Patel, P; Bercik, P; Morgan, DG; Bolino, C; Pintos-Sanchez, MI; Moayyedi, P; Ford, AC
Published in: Scandinavian journal of gastroenterology
July 2015

Guidelines for the management of irritable bowel syndrome (IBS) encourage a positive diagnosis, but some evidence suggests organic disease may be missed unless investigations are performed. We examined yield of colonoscopy in a cohort of secondary care patients meeting criteria for IBS.Demographic data, symptoms and findings at colonoscopy were recorded prospectively in consecutive, unselected adults with gastrointestinal (GI) symptoms compatible with IBS according to the Rome III criteria. Prevalence of organic GI disease was compared between those meeting criteria for IBS, according to the presence or absence of co-existent alarm features, and by IBS subtype.A total of 559 patients met Rome III criteria for IBS, of whom 423 reported ≥1 alarm feature and 136 none. There was a significantly higher prevalence of organic GI disease among those reporting alarm features (117 [27.7%]), compared with those without (21 [15.4%]) (p = 0.002). In the latter group of 136 patients, Crohn's disease was the commonest finding (10 [7.4%] subjects), followed by coeliac disease (4 [2.9%] subjects), and microscopic colitis (3 [2.2%] subjects). Regardless of presence or absence of alarm features, patients with constipation-predominant IBS were less likely to exhibit organic GI disease than those with diarrhea-predominant or mixed IBS (12.7% vs. 32.1% and 23.8%, p = 0.006).One in six patients with symptoms compatible with IBS without alarm features in this selected group exhibited organic GI disease following investigation. Assessment of alarm features in a comprehensive history is vital to reduce diagnostic uncertainty that can surround IBS.

Published In

Scandinavian journal of gastroenterology

DOI

EISSN

1502-7708

ISSN

0036-5521

Publication Date

July 2015

Volume

50

Issue

7

Start / End Page

816 / 823

Related Subject Headings

  • Young Adult
  • Prospective Studies
  • Middle Aged
  • Male
  • Irritable Bowel Syndrome
  • Humans
  • Gastrointestinal Diseases
  • Gastroenterology & Hepatology
  • Female
  • Diarrhea
 

Citation

APA
Chicago
ICMJE
MLA
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Patel, P., Bercik, P., Morgan, D. G., Bolino, C., Pintos-Sanchez, M. I., Moayyedi, P., & Ford, A. C. (2015). Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey. Scandinavian Journal of Gastroenterology, 50(7), 816–823. https://doi.org/10.3109/00365521.2015.1007079
Patel, Purav, Premysl Bercik, David G. Morgan, Carolina Bolino, Maria Ines Pintos-Sanchez, Paul Moayyedi, and Alexander C. Ford. “Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey.Scandinavian Journal of Gastroenterology 50, no. 7 (July 2015): 816–23. https://doi.org/10.3109/00365521.2015.1007079.
Patel P, Bercik P, Morgan DG, Bolino C, Pintos-Sanchez MI, Moayyedi P, et al. Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey. Scandinavian journal of gastroenterology. 2015 Jul;50(7):816–23.
Patel, Purav, et al. “Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey.Scandinavian Journal of Gastroenterology, vol. 50, no. 7, July 2015, pp. 816–23. Epmc, doi:10.3109/00365521.2015.1007079.
Patel P, Bercik P, Morgan DG, Bolino C, Pintos-Sanchez MI, Moayyedi P, Ford AC. Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey. Scandinavian journal of gastroenterology. 2015 Jul;50(7):816–823.

Published In

Scandinavian journal of gastroenterology

DOI

EISSN

1502-7708

ISSN

0036-5521

Publication Date

July 2015

Volume

50

Issue

7

Start / End Page

816 / 823

Related Subject Headings

  • Young Adult
  • Prospective Studies
  • Middle Aged
  • Male
  • Irritable Bowel Syndrome
  • Humans
  • Gastrointestinal Diseases
  • Gastroenterology & Hepatology
  • Female
  • Diarrhea