Primary biliary cirrhosis and type II autoimmune polyglandular syndrome.

Published

Journal Article

A 45-year-old female was diagnosed with Hashimoto's thyroiditis in 1976 and Addison's disease in 1979. At that time, her antimitochondrial antibody (AMA) level was elevated at 1:32. She subsequently developed premature ovarian failure and type I diabetes mellitus. In 1996, she became jaundiced with a cholestatic enzyme pattern. AMA was positive at a titre of 1:256. A liver biopsy confirmed the diagnosis of primary biliary cirrhosis (PBC). She underwent a liver transplantation in January 1998. This is the first report of PBC in association with type II autoimmune polyglandular syndrome. The association of PBC with other organ-specific autoimmune diseases supports an immune-mediated pathogenesis and may have implications in further studies of PBC.

Full Text

Cited Authors

  • Borgaonkar, MR; Morgan, DG

Published Date

  • November 1999

Published In

Volume / Issue

  • 13 / 9

Start / End Page

  • 767 - 770

PubMed ID

  • 10633830

Pubmed Central ID

  • 10633830

Electronic International Standard Serial Number (EISSN)

  • 1916-7237

International Standard Serial Number (ISSN)

  • 0835-7900

Digital Object Identifier (DOI)

  • 10.1155/1999/810264

Language

  • eng