Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.

Journal Article (Journal Article)

Understanding resistance to BCL2 inhibition is a critical scientific and clinical challenge. In this issue of Cancer Discovery, two laboratories use unbiased approaches of large loss-of-function CRISPR/Cas 9 screens to discover targetable liabilities in cell signaling and metabolism to acute myeloid leukemia resistant to BCL2 inhibition.See related article by Chen et al., p. 890.See related article by Nechiporuk et al., p. 910.

Full Text

Duke Authors

Cited Authors

  • Savona, MR; Rathmell, JC

Published Date

  • July 2019

Published In

Volume / Issue

  • 9 / 7

Start / End Page

  • 831 - 833

PubMed ID

  • 31262744

Pubmed Central ID

  • PMC8059329

Electronic International Standard Serial Number (EISSN)

  • 2159-8290

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-19-0510


  • eng

Conference Location

  • United States