Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.
Journal Article (Journal Article)
Understanding resistance to BCL2 inhibition is a critical scientific and clinical challenge. In this issue of Cancer Discovery, two laboratories use unbiased approaches of large loss-of-function CRISPR/Cas 9 screens to discover targetable liabilities in cell signaling and metabolism to acute myeloid leukemia resistant to BCL2 inhibition.See related article by Chen et al., p. 890.See related article by Nechiporuk et al., p. 910.
Full Text
Duke Authors
Cited Authors
- Savona, MR; Rathmell, JC
Published Date
- July 2019
Published In
Volume / Issue
- 9 / 7
Start / End Page
- 831 - 833
PubMed ID
- 31262744
Pubmed Central ID
- PMC8059329
Electronic International Standard Serial Number (EISSN)
- 2159-8290
Digital Object Identifier (DOI)
- 10.1158/2159-8290.CD-19-0510
Language
- eng
Conference Location
- United States