Glutamine in Burn Injury.

Published

Journal Article (Review)

Burn injury is the most devastating of survivable injuries and is a worldwide public health crisis. Burn injury is among the most severe metabolic stresses a patient can sustain. A major burn leads to an inflammatory response and catabolism that, when compounded by burn wound nutrient losses, can lead to severe nutrition losses and deficiencies. These losses can impair immune function and wound healing and place burn patients at high risk for organ injury and mortality. Experimental data indicate glutamine (GLN) is well positioned mechanistically, perhaps above and beyond in any other intensive care unit setting, to improve outcome in burn-injured patients. Initial clinical trial data have also shown a consistent signal of reduced mortality and reduced hospital length of stay in burn-injured subjects, without signals of clinical risk. A number of GLN clinical trials demonstrate significant reductions of gram-negative bacteremia in burn injury, perhaps via maintenance of the gut barrier or gut immune function. Current societal recommendations continue to suggest the use of GLN in burn injury. The promising clinical data in burn-injured patients, with no signals of harm, have warranted study of GLN in the definitive RE-ENERGIZE trial, which is now ongoing.

Full Text

Duke Authors

Cited Authors

  • Wischmeyer, PE

Published Date

  • October 2019

Published In

Volume / Issue

  • 34 / 5

Start / End Page

  • 681 - 687

PubMed ID

  • 31270877

Pubmed Central ID

  • 31270877

Electronic International Standard Serial Number (EISSN)

  • 1941-2452

Digital Object Identifier (DOI)

  • 10.1002/ncp.10362

Language

  • eng

Conference Location

  • United States