Developmental pharmacogenomics.
Published
Journal Article (Review)
Interindividual variability in the disposition and action associated with similar doses of a given medication is an inherent characteristic of both adult and pediatric populations. Genotype-phenotype relationships in infants and children must take into account the role that ontogeny plays in producing variability in both pharmacokinetics and pharmacodynamics. This review explores pharmacogenomics in the context of ontogeny and relates these to the expression of drug-metabolizing enzymes and transporters and the consequent effect on the exposure-response relationship in the early years of life.
Full Text
Duke Authors
Cited Authors
- Neville, KA; Becker, ML; Goldman, JL; Kearns, GL
Published Date
- March 2011
Published In
Volume / Issue
- 21 / 3
Start / End Page
- 255 - 265
PubMed ID
- 21320234
Pubmed Central ID
- 21320234
Electronic International Standard Serial Number (EISSN)
- 1460-9592
Digital Object Identifier (DOI)
- 10.1111/j.1460-9592.2011.03533.x
Language
- eng
Conference Location
- France