Developmental pharmacogenomics.

Journal Article (Journal Article;Review)

Interindividual variability in the disposition and action associated with similar doses of a given medication is an inherent characteristic of both adult and pediatric populations. Genotype-phenotype relationships in infants and children must take into account the role that ontogeny plays in producing variability in both pharmacokinetics and pharmacodynamics. This review explores pharmacogenomics in the context of ontogeny and relates these to the expression of drug-metabolizing enzymes and transporters and the consequent effect on the exposure-response relationship in the early years of life.

Full Text

Duke Authors

Cited Authors

  • Neville, KA; Becker, ML; Goldman, JL; Kearns, GL

Published Date

  • March 2011

Published In

Volume / Issue

  • 21 / 3

Start / End Page

  • 255 - 265

PubMed ID

  • 21320234

Electronic International Standard Serial Number (EISSN)

  • 1460-9592

Digital Object Identifier (DOI)

  • 10.1111/j.1460-9592.2011.03533.x


  • eng

Conference Location

  • France