Development of biomarkers to optimize pediatric patient management: what makes children different?

Journal Article (Journal Article;Review)

Despite the frequent utilization of biomarkers in medical practice, there is a relative paucity of information regarding validated pediatric biomarkers. Frequently, biomarkers found to be efficacious in adults are extrapolated to the pediatric clinical setting without considering that the pathogenesis of many diseases is distinctly different in children, and ontogeny directly influences disease evolution and therapeutic response in children. New and innovative approaches are necessary to provide reliable, validated biomarkers that can be used to improve and advance pediatric medical care.

Full Text

Duke Authors

Cited Authors

  • Goldman, J; Becker, ML; Jones, B; Clements, M; Leeder, JS

Published Date

  • December 2011

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 781 - 794

PubMed ID

  • 22103612

Pubmed Central ID

  • PMC3321646

Electronic International Standard Serial Number (EISSN)

  • 1752-0371

Digital Object Identifier (DOI)

  • 10.2217/bmm.11.96


  • eng

Conference Location

  • England