Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.

Journal Article (Journal Article)

To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

Full Text

Duke Authors

Cited Authors

  • Gehrig, JL; Venkatesh, S; Chang, H-W; Hibberd, MC; Kung, VL; Cheng, J; Chen, RY; Subramanian, S; Cowardin, CA; Meier, MF; O'Donnell, D; Talcott, M; Spears, LD; Semenkovich, CF; Henrissat, B; Giannone, RJ; Hettich, RL; Ilkayeva, O; Muehlbauer, M; Newgard, CB; Sawyer, C; Head, RD; Rodionov, DA; Arzamasov, AA; Leyn, SA; Osterman, AL; Hossain, MI; Islam, M; Choudhury, N; Sarker, SA; Huq, S; Mahmud, I; Mostafa, I; Mahfuz, M; Barratt, MJ; Ahmed, T; Gordon, JI

Published Date

  • July 12, 2019

Published In

Volume / Issue

  • 365 / 6449

PubMed ID

  • 31296738

Pubmed Central ID

  • PMC6683325

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.aau4732


  • eng

Conference Location

  • United States