Translational impact of NIH-funded nonhuman primate research in transplantation.

Journal Article (Journal Article;Review)

The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.

Full Text

Duke Authors

Cited Authors

  • Knechtle, SJ; Shaw, JM; Hering, BJ; Kraemer, K; Madsen, JC

Published Date

  • July 10, 2019

Published In

Volume / Issue

  • 11 / 500

PubMed ID

  • 31292263

Pubmed Central ID

  • PMC7197021

Electronic International Standard Serial Number (EISSN)

  • 1946-6242

Digital Object Identifier (DOI)

  • 10.1126/scitranslmed.aau0143


  • eng

Conference Location

  • United States