Translational impact of NIH-funded nonhuman primate research in transplantation.
Journal Article (Journal Article;Review)
The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.
Full Text
Duke Authors
Cited Authors
- Knechtle, SJ; Shaw, JM; Hering, BJ; Kraemer, K; Madsen, JC
Published Date
- July 10, 2019
Published In
Volume / Issue
- 11 / 500
PubMed ID
- 31292263
Pubmed Central ID
- PMC7197021
Electronic International Standard Serial Number (EISSN)
- 1946-6242
Digital Object Identifier (DOI)
- 10.1126/scitranslmed.aau0143
Language
- eng
Conference Location
- United States