Novel therapies for epilepsy in the pipeline.
Journal Article (Journal Article;Review)
Despite the availability of many antiepileptic drugs (AEDs) (old and newly developed) and, as recently suggested, their optimization in the treatment of patients with uncontrolled seizures, more than 30% of patients with epilepsy continue to experience seizures and have drug-resistant epilepsy; the management of these patients represents a real challenge for epileptologists and researchers. Resective surgery with the best rates of seizure control is not an option for all of them; therefore, research and discovery of new methods of treating resistant epilepsy are of extreme importance. In this article, we will discuss some innovative approaches, such as P-glycoprotein (P-gp) inhibitors, gene therapy, stem cell therapy, traditional and novel antiepileptic devices, precision medicine, as well as therapeutic advances in epileptic encephalopathy in children; these treatment modalities open up new horizons for the treatment of patients with drug-resistant epilepsy.
- Mesraoua, B; Deleu, D; Kullmann, DM; Shetty, AK; Boon, P; Perucca, E; Mikati, MA; Asadi-Pooya, AA
- August 2019
Volume / Issue
- 97 /
Start / End Page
- 282 - 290
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States