Novel therapies for epilepsy in the pipeline.

Journal Article (Journal Article;Review)

Despite the availability of many antiepileptic drugs (AEDs) (old and newly developed) and, as recently suggested, their optimization in the treatment of patients with uncontrolled seizures, more than 30% of patients with epilepsy continue to experience seizures and have drug-resistant epilepsy; the management of these patients represents a real challenge for epileptologists and researchers. Resective surgery with the best rates of seizure control is not an option for all of them; therefore, research and discovery of new methods of treating resistant epilepsy are of extreme importance. In this article, we will discuss some innovative approaches, such as P-glycoprotein (P-gp) inhibitors, gene therapy, stem cell therapy, traditional and novel antiepileptic devices, precision medicine, as well as therapeutic advances in epileptic encephalopathy in children; these treatment modalities open up new horizons for the treatment of patients with drug-resistant epilepsy.

Full Text

Duke Authors

Cited Authors

  • Mesraoua, B; Deleu, D; Kullmann, DM; Shetty, AK; Boon, P; Perucca, E; Mikati, MA; Asadi-Pooya, AA

Published Date

  • August 2019

Published In

Volume / Issue

  • 97 /

Start / End Page

  • 282 - 290

PubMed ID

  • 31284159

Electronic International Standard Serial Number (EISSN)

  • 1525-5069

Digital Object Identifier (DOI)

  • 10.1016/j.yebeh.2019.04.042


  • eng

Conference Location

  • United States