The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD).

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: Here, we discuss how esophageal motor testing plays important roles in patients with suspected gastroesophageal reflux disease (GERD). In addition to guiding appropriate placement of catheters for ambulatory reflux monitoring, esophageal high-resolution manometry (HRM) rules out confounding diagnoses, such as achalasia spectrum disorders, that can present with symptoms similar to that of GERD, but are managed very differently. RECENT FINDINGS: HRM performed with impedance in the post-prandial setting (PP-HRIM) can assess for rumination syndrome or supragastric belching, which should be directed towards behavioral interventions. The recent GERD Classification of Motor Function recommends a hierarchical approach, focusing on (1) the esophagogastric junction (EGJ), (2) the esophageal body, and (3) esophageal contraction reserve, which can be assessed with provocative maneuvers at HRM, such as multiple rapid swallows (MRS). This approach can inform the appropriate tailoring of antireflux surgery. Novel esophageal motility metrics, such as the EGJ-contractile integral from HRM, or post-reflux swallow-induced peristaltic wave indices from 24-h pH-impedance monitoring, may also assist with GERD diagnosis. Assessment of esophageal motor function can contribute in a significant manner to the care of patients with suspected GERD, particularly when esophageal symptoms do not improve with antisecretory therapy, and/or when surgical or endoscopic antireflux therapies are under consideration.

Full Text

Duke Authors

Cited Authors

  • Garbarino, S; Horton, A; Patel, A

Published Date

  • July 10, 2019

Published In

Volume / Issue

  • 21 / 8

Start / End Page

  • 37 -

PubMed ID

  • 31289922

Electronic International Standard Serial Number (EISSN)

  • 1534-312X

Digital Object Identifier (DOI)

  • 10.1007/s11894-019-0704-7


  • eng

Conference Location

  • United States