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Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients.

Publication ,  Journal Article
Tsilimigras, DI; Hyer, JM; Moris, D; Sahara, K; Bagante, F; Guglielmi, A; Aldrighetti, L; Alexandrescu, S; Marques, HP; Shen, F; Koerkamp, BG ...
Published in: Journal of surgical oncology
August 2019

The objective of the current study was to define the impact of albumin-bilirubin (ALBI) grade on short- as well as long-term outcomes among patients with intrahepatic cholangiocarcinoma (ICC).Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified using an international multi-institutional database. Clinicopathologic factors including ALBI score were assessed using bivariate and multivariable analyses, as well as standard survival analyses.Among 706 patients, 453 (64.2%) patients had ALBI grade 1, 231 (32.7%) ALBI grade 2, and 22 (3.1%) had ALBI grade 3. After adjusting for all competing factors, patients with ALBI grade 2/3 had higher odds of a prolonged length-of-stay (>10 days, odds ratio [OR] = 2.37, 95% confidence interval [CI]:1.47-3.80), perioperative transfusion (OR = 2.15, 95% CI:1.45-3.18) and 90-day mortality (OR = 2.50, 95% CI:1.16-5.38). Median and 5-year overall survival (OS) for the entire cohort was 41.5 months (IQR:15.7-107.8) and 39.8%, respectively. Of note, median OS incrementally worsened with increased ALBI grade: grade 1, 49.6 months (IQR:18.3-NR) vs grade 2, 29.6 months (IQR:12.6-98.4) vs grade 3, 16.9 months (IQR:6.5-32.4; P < 0.001). On multivariable analysis, higher ALBI grade remained associated with higher hazards of death (grade 2/3: hazard ratio = 1.36, 95% CI:1.04-1.78).The ALBI score was associated with both short- and long-term outcomes following resection for ICC and could prove a useful surrogate marker to identify patients at risk for adverse outcomes.

Duke Scholars

Published In

Journal of surgical oncology

DOI

EISSN

1096-9098

ISSN

0022-4790

Publication Date

August 2019

Volume

120

Issue

2

Start / End Page

206 / 213

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Serum Albumin
  • Retrospective Studies
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Hepatectomy
 

Citation

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Tsilimigras, D. I., Hyer, J. M., Moris, D., Sahara, K., Bagante, F., Guglielmi, A., … other members of the International Intrahepatic Cholangiocarcinoma Study Group, . (2019). Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients. Journal of Surgical Oncology, 120(2), 206–213. https://doi.org/10.1002/jso.25486
Tsilimigras, Diamantis I., J Madison Hyer, Dimitrios Moris, Kota Sahara, Fabio Bagante, Alfredo Guglielmi, Luca Aldrighetti, et al. “Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients.Journal of Surgical Oncology 120, no. 2 (August 2019): 206–13. https://doi.org/10.1002/jso.25486.
Tsilimigras DI, Hyer JM, Moris D, Sahara K, Bagante F, Guglielmi A, et al. Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients. Journal of surgical oncology. 2019 Aug;120(2):206–13.
Tsilimigras, Diamantis I., et al. “Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients.Journal of Surgical Oncology, vol. 120, no. 2, Aug. 2019, pp. 206–13. Epmc, doi:10.1002/jso.25486.
Tsilimigras DI, Hyer JM, Moris D, Sahara K, Bagante F, Guglielmi A, Aldrighetti L, Alexandrescu S, Marques HP, Shen F, Koerkamp BG, Endo I, Pawlik TM, other members of the International Intrahepatic Cholangiocarcinoma Study Group. Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients. Journal of surgical oncology. 2019 Aug;120(2):206–213.
Journal cover image

Published In

Journal of surgical oncology

DOI

EISSN

1096-9098

ISSN

0022-4790

Publication Date

August 2019

Volume

120

Issue

2

Start / End Page

206 / 213

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Serum Albumin
  • Retrospective Studies
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Hepatectomy