Outcomes of Treatment of Gestational Trophoblastic Neoplasia in a Primarily Indigent Urban Population.


Journal Article

OBJECTIVE: To review outcomes of women with gestational trophoblastic neoplasia (GTN) who presented to an inner-city hospital system, given that the rigorous treatment and follow-up for GTN is often problematic for certain women of low socioeconomic status with limited resources and social support. STUDY DESIGN: A retrospective review was performed with IRB approval of patients diagnosed with GTN based on the revised WHO scoring system from 1999-2010 at our institution. SPSS Statistics software was used to perform univariate and multivariate analyses. RESULTS: Forty-nine patients were treated for GTN: 32 low-risk and 17 high-risk. Low-risk patients received an average of 5 cycles of initial single-agent chemotherapy. Six patients had persistent disease and were switched to a second single-agent regimen. One patient required multiagent chemotherapy for normalization of human chorionic gonadotropin levels. No patient had recurrence of disease. All high-risk patients were initially treated with multiagent chemotherapy, averaging 8 cycles. Two of the 17 patients persisted; 1 recurred. All 3 currently have no evidence of disease. No patient died of disease. CONCLUSION: Excellent treatment outcomes in patients with GTN may be achieved in disadvantaged populations when compliance to regimens is optimized.

Full Text

Duke Authors

Cited Authors

  • Davidson, BA; Nagel, CI; Richardson, DL; Kehoe, SM; Miller, DS; Lea, JS

Published Date

  • May 2015

Published In

Volume / Issue

  • 60 / 5-6

Start / End Page

  • 243 - 248

PubMed ID

  • 26126310

Pubmed Central ID

  • 26126310

International Standard Serial Number (ISSN)

  • 0024-7758


  • eng

Conference Location

  • United States