A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples.

Journal Article (Journal Article)

Accumulating research suggests that the pro-inflammatory cytokine interleukin-1β (IL-1β) has a modulatory effect on the hippocampus, a brain structure important for learning and memory as well as linked with both psychiatric and neurodegenerative disorders. Here, we used an imaging genetics strategy to test an association between an IL-1β polygenic score and hippocampal volume in two independent samples. Our polygenic score was derived using summary statistics from a recent genome-wide association study of circulating cytokines that included IL-1β (N = 3,309). In the first sample of 512 non-Hispanic Caucasian university students (274 women, mean age 19.78 ± 1.24 years) from the Duke Neurogenetics Study, we identified a significant positive correlation between IL-1β polygenic scores and hippocampal volume. This positive association was successfully replicated in a second sample of 7,960 white British volunteers (4,158 women, mean age 62.63 ± 7.45 years) from the UK Biobank. Our results lend further support in humans, to the link between IL-1β and the structure of the hippocampus.

Full Text

Duke Authors

Cited Authors

  • Avinun, R; Nevo, A; Knodt, AR; Elliott, ML; Hariri, AR

Published Date

  • September 2019

Published In

Volume / Issue

  • 40 / 13

Start / End Page

  • 3910 - 3917

PubMed ID

  • 31119842

Pubmed Central ID

  • PMC6679724

Electronic International Standard Serial Number (EISSN)

  • 1097-0193

International Standard Serial Number (ISSN)

  • 1065-9471

Digital Object Identifier (DOI)

  • 10.1002/hbm.24639


  • eng