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A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples.

Publication ,  Journal Article
Avinun, R; Nevo, A; Knodt, AR; Elliott, ML; Hariri, AR
Published in: Human brain mapping
September 2019

Accumulating research suggests that the pro-inflammatory cytokine interleukin-1β (IL-1β) has a modulatory effect on the hippocampus, a brain structure important for learning and memory as well as linked with both psychiatric and neurodegenerative disorders. Here, we used an imaging genetics strategy to test an association between an IL-1β polygenic score and hippocampal volume in two independent samples. Our polygenic score was derived using summary statistics from a recent genome-wide association study of circulating cytokines that included IL-1β (N = 3,309). In the first sample of 512 non-Hispanic Caucasian university students (274 women, mean age 19.78 ± 1.24 years) from the Duke Neurogenetics Study, we identified a significant positive correlation between IL-1β polygenic scores and hippocampal volume. This positive association was successfully replicated in a second sample of 7,960 white British volunteers (4,158 women, mean age 62.63 ± 7.45 years) from the UK Biobank. Our results lend further support in humans, to the link between IL-1β and the structure of the hippocampus.

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Published In

Human brain mapping

DOI

EISSN

1097-0193

ISSN

1065-9471

Publication Date

September 2019

Volume

40

Issue

13

Start / End Page

3910 / 3917

Related Subject Headings

  • Young Adult
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Interleukin-1beta
  • Inflammation
  • Humans
  • Hippocampus
  • Genome-Wide Association Study
  • Female
 

Citation

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Avinun, R., Nevo, A., Knodt, A. R., Elliott, M. L., & Hariri, A. R. (2019). A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples. Human Brain Mapping, 40(13), 3910–3917. https://doi.org/10.1002/hbm.24639
Avinun, Reut, Adam Nevo, Annchen R. Knodt, Maxwell L. Elliott, and Ahmad R. Hariri. “A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples.Human Brain Mapping 40, no. 13 (September 2019): 3910–17. https://doi.org/10.1002/hbm.24639.
Avinun R, Nevo A, Knodt AR, Elliott ML, Hariri AR. A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples. Human brain mapping. 2019 Sep;40(13):3910–7.
Avinun, Reut, et al. “A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples.Human Brain Mapping, vol. 40, no. 13, Sept. 2019, pp. 3910–17. Epmc, doi:10.1002/hbm.24639.
Avinun R, Nevo A, Knodt AR, Elliott ML, Hariri AR. A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples. Human brain mapping. 2019 Sep;40(13):3910–3917.
Journal cover image

Published In

Human brain mapping

DOI

EISSN

1097-0193

ISSN

1065-9471

Publication Date

September 2019

Volume

40

Issue

13

Start / End Page

3910 / 3917

Related Subject Headings

  • Young Adult
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Interleukin-1beta
  • Inflammation
  • Humans
  • Hippocampus
  • Genome-Wide Association Study
  • Female