Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.

Published

Journal Article

Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.

Full Text

Duke Authors

Cited Authors

  • Nunnery, JK; Engene, N; Byrum, T; Cao, Z; Jabba, SV; Pereira, AR; Matainaho, T; Murray, TF; Gerwick, WH

Published Date

  • May 2012

Published In

Volume / Issue

  • 77 / 9

Start / End Page

  • 4198 - 4208

PubMed ID

  • 22489775

Pubmed Central ID

  • 22489775

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo300160e

Language

  • eng