Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.
Published
Journal Article
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.
Full Text
Duke Authors
Cited Authors
- Nunnery, JK; Engene, N; Byrum, T; Cao, Z; Jabba, SV; Pereira, AR; Matainaho, T; Murray, TF; Gerwick, WH
Published Date
- May 2012
Published In
Volume / Issue
- 77 / 9
Start / End Page
- 4198 - 4208
PubMed ID
- 22489775
Pubmed Central ID
- 22489775
Electronic International Standard Serial Number (EISSN)
- 1520-6904
International Standard Serial Number (ISSN)
- 0022-3263
Digital Object Identifier (DOI)
- 10.1021/jo300160e
Language
- eng