Correlation of spectral-domain optical coherence tomography with fundus fluorescein angiography in an infant with retinal hamartomas.
To describe the correlation between the surface morphology on spectral-domain optical coherence tomography (SD-OCT) and leakage pattern on fundus fluorescein angiography (FFA) in an infant with multiple retinal hamartomas.An Asian Indian female infant was found to have 2 retinal lesions in the right eye and 1 in the left eye during Retcam (Clarity MSI, CA, USA) screening for retinopathy of prematurity at 45 weeks postmenstrual age. Spectral-domain optical coherence tomography on the hand-held OCT (Envisu 2300, Bioptigen, NC, USA) and FFA on the Retcam 3 were performed under monitoring in the office.Spectral-domain OCT detected all 3 lesions but only 1 lesion was detected on FFA. While this lesion had an irregular surface with overlying vitreoretinal (VR) traction on SD-OCT, the other 2 lesions not detected on FFA were smooth and had no VR traction. After a follow-up to 18 months corrected age, there was no change in the morphology of any of the lesions.It is possible to characterize retinal hamartomas in infants using SD-OCT and correlate them with FFA. Spectral-domain OCT examination can be used to diagnose and monitor lesions even if they are not detectable on angiography.
Chidambara, L; Jayadev, C; Mangalesh, S; Sivakumar, M; Shetty, B; Vinekar, A
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