Macular edema in Asian Indian premature infants with retinopathy of prematurity: Impact on visual acuity and refractive status after 1-year.

Published

Journal Article

To report the impact of transient, self-resolving, untreated "macular edema" detected on spectral domain optical coherence tomography in Asian Indian premature infants with retinopathy of prematurity (ROP) on visual acuity (VA) and refraction at 1-year of corrected age.Visual acuity and refraction of 11 infants with bilateral macular edema (Group A) was compared with gestational age-matched 16 infants with ROP without edema (Group B) and 17 preterms infants without ROP and without edema (Group C) at 3, 6, 9 and 12 months of corrected age using Teller Acuity Cards and cycloplegic retinoscopy. Sub-group analysis of the previously described pattern A and B macular edema was performed.Visual acuity was lower in infants with macular edema compared with the other two control groups throughout the study period, but statistically significant only at 3 months. Visual improvement in these infants was highest between the 3 rd and 6 th month and plateaued by the end of the 1 st year with acuity comparable to the other two groups. The edema cohort was more hyperopic compared to the other two groups between 3 and 12 months of age. Pattern A edema had worse VA compared to pattern B, although not statistically significant.Macular edema, although transient, caused reduced VA as early as 3 months of corrected age in Asian Indian premature infants weighing <2000 g at birth. The higher hyperopia in these infants is possibly due to visual disturbances caused at a critical time of fovealization. We hypothesize a recovery and feedback mechanism based on the principles of active emmetropization to explain our findings.

Full Text

Cited Authors

  • Vinekar, A; Mangalesh, S; Jayadev, C; Bauer, N; Munusamy, S; Kemmanu, V; Kurian, M; Mahendradas, P; Avadhani, K; Shetty, B

Published Date

  • May 2015

Published In

Volume / Issue

  • 63 / 5

Start / End Page

  • 432 - 437

PubMed ID

  • 26139806

Pubmed Central ID

  • 26139806

Electronic International Standard Serial Number (EISSN)

  • 1998-3689

International Standard Serial Number (ISSN)

  • 0301-4738

Digital Object Identifier (DOI)

  • 10.4103/0301-4738.159879

Language

  • eng