Structural and Function Correlation of Cone Packing Utilizing Adaptive Optics and Microperimetry.


Journal Article

To assess the functional aspects of cone mosaic and correlate cone packing with retinal sensitivity utilizing microperimetry in emmetropes at different eccentricities.Twenty-four healthy volunteers underwent microperimetry (MAIA Centervue, Italy) and assessment of photoreceptors using adaptive optics retinal camera, rtx1 (Imagine Eyes, Orsay, France), at 2 and 3 degrees from the foveal centre in 4 quadrants: superior, inferior, temporal, and nasal. Data was analyzed using SPSS version 17 (IBM). Spearman's correlation tests were used to establish correlation between mean cone packing density and retinal sensitivity at different quadrants.Thirteen females and 11 males (age range 20-40 years) were included. The cone density was found to be significantly different among all quadrants (temporal = 25786.68/mm(2) ± 4367.07/mm(2), superior = 23009.35/mm(2) ± 5415.81/mm(2), nasal = 22838.09/mm(2) ± 4166.22/mm(2), and inferior = 21097.53/mm(2) ± 4235.84/mm(2)). A statistical significance (P < 0.008) was found between orthogonal meridians, that is, temporal, nasal (48624.77/mm(2))> superior, inferior (44106.88/mm(2)). A drop in retinal sensitivity was observed as the eccentricity increased (P < 0.05). It was also found that as cone packing density decreased retinal sensitivity also decreased (P < 0.05) in all quadrants. This was observed at both 2 and 3 degrees.It is of crucial importance to establish normative variations in cone structure-function correlation. This may help in detection of subtle pathology and its early intervention.

Full Text

Cited Authors

  • Supriya, D; Shwetha, M; Kiran Anupama, K; Kummelil Mathew, K; Berendschot, TTJM; Schouten, JSAG; Bharamshetter, R; Naresh, YK; Rohit, S; Hegde, B

Published Date

  • January 2015

Published In

Volume / Issue

  • 2015 /

Start / End Page

  • 968672 -

PubMed ID

  • 26167509

Pubmed Central ID

  • 26167509

Electronic International Standard Serial Number (EISSN)

  • 2314-6141

International Standard Serial Number (ISSN)

  • 2314-6133

Digital Object Identifier (DOI)

  • 10.1155/2015/968672


  • eng