Novel RNA modifications in the nervous system: form and function.

Journal Article (Journal Article;Review)

Modified RNA molecules have recently been shown to regulate nervous system functions. This mini-review and associated mini-symposium provide an overview of the types and known functions of novel modified RNAs in the nervous system, including covalently modified RNAs, edited RNAs, and circular RNAs. We discuss basic molecular mechanisms involving RNA modifications as well as the impact of modified RNAs and their regulation on neuronal processes and disorders, including neural fate specification, intellectual disability, neurodegeneration, dopamine neuron function, and substance use disorders.

Full Text

Duke Authors

Cited Authors

  • Satterlee, JS; Basanta-Sanchez, M; Blanco, S; Li, JB; Meyer, K; Pollock, J; Sadri-Vakili, G; Rybak-Wolf, A

Published Date

  • November 12, 2014

Published In

Volume / Issue

  • 34 / 46

Start / End Page

  • 15170 - 15177

PubMed ID

  • 25392485

Pubmed Central ID

  • 25392485

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.3236-14.2014


  • eng

Conference Location

  • United States