Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T.

Journal Article (Journal Article)

Studying the human subcortical auditory system non-invasively is challenging due to its small, densely packed structures deep within the brain. Additionally, the elaborate three-dimensional (3-D) structure of the system can be difficult to understand based on currently available 2-D schematics and animal models. Wfe addressed these issues using a combination of histological data, post mortem magnetic resonance imaging (MRI), and in vivo MRI at 7 Tesla. We created anatomical atlases based on state-of-the-art human histology (BigBrain) and postmortem MRI (50 µm). We measured functional MRI (fMRI) responses to natural sounds and demonstrate that the functional localization of subcortical structures is reliable within individual participants who were scanned in two different experiments. Further, a group functional atlas derived from the functional data locates these structures with a median distance below 2 mm. Using diffusion MRI tractography, we revealed structural connectivity maps of the human subcortical auditory pathway both in vivo (1050 µm isotropic resolution) and post mortem (200 µm isotropic resolution). This work captures current MRI capabilities for investigating the human subcortical auditory system, describes challenges that remain, and contributes novel, openly available data, atlases, and tools for researching the human auditory system.

Full Text

Duke Authors

Cited Authors

  • Sitek, KR; Gulban, OF; Calabrese, E; Johnson, GA; Lage-Castellanos, A; Moerel, M; Ghosh, SS; De Martino, F

Published Date

  • August 1, 2019

Published In

Volume / Issue

  • 8 /

PubMed ID

  • 31368891

Pubmed Central ID

  • PMC6707786

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.48932

Language

  • eng

Conference Location

  • England