A statistical and biological response to an informatics appraisal of healthy aging gene signatures.

Journal Article (Letter)

Jacob and Speed did not identify even a single example of a '150-gene-set' that was statistically significant at classifying Alzheimer's disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.

Full Text

Duke Authors

Cited Authors

  • Timmons, JA; Gallagher, IJ; Sood, S; Phillips, B; Crossland, H; Howard, R; Kraus, WE; Atherton, PJ

Published Date

  • August 2, 2019

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 152 -

PubMed ID

  • 31375147

Pubmed Central ID

  • PMC6676519

Electronic International Standard Serial Number (EISSN)

  • 1474-760X

Digital Object Identifier (DOI)

  • 10.1186/s13059-019-1734-z


  • eng

Conference Location

  • England