Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy.

Published online

Journal Article (Review)

Traumatic brain injury (TBI) and status epilepticus (SE) have both been linked to development of human epilepsy. Although distinct etiologies, current research has suggested the convergence of molecular mechanisms underlying epileptogenesis following these insults. One such mechanism involves the neurotrophin brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin related kinase B (TrkB). In this review, we focus on currently available data regarding the pathophysiologic role of BDNF/TrkB signaling in epilepsy development. We specifically examine the axonal injury and SE epilepsy models, two animal models that recapitulate many aspects of TBI- and SE-induced epilepsy in humans respectively. Thereafter, we discuss aspiring strategies for targeting BDNF/TrkB signaling so as to prevent epilepsy following an insult or suppress its expression once developed.

Full Text

Duke Authors

Cited Authors

  • Lin, TW; Harward, SC; Huang, YZ; McNamara, JO

Published Date

  • August 1, 2019

Published In

Start / End Page

  • 107734 -

PubMed ID

  • 31377199

Pubmed Central ID

  • 31377199

Electronic International Standard Serial Number (EISSN)

  • 1873-7064

Digital Object Identifier (DOI)

  • 10.1016/j.neuropharm.2019.107734

Language

  • eng

Conference Location

  • England