A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration.

Journal Article (Journal Article;Review)

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or "wet" form of AMD, no therapy is successful for the non-neovascular or "dry" form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.

Full Text

Duke Authors

Cited Authors

  • Handa, JT; Bowes Rickman, C; Dick, AD; Gorin, MB; Miller, JW; Toth, CA; Ueffing, M; Zarbin, M; Farrer, LA

Published Date

  • July 26, 2019

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 3347 -

PubMed ID

  • 31350409

Pubmed Central ID

  • PMC6659646

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-019-11262-1


  • eng

Conference Location

  • England