Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial.

Journal Article

OBJECTIVE: To assess visual function 15 years after acute unilateral optic neuritis. DESIGN: Longitudinal follow-up of a randomized clinical trial. PARTICIPANTS: Two hundred ninety-four patients who were randomized in the Optic Neuritis Treatment Trial between 1988 and 1991 and underwent examination in 2006. TESTING: A neuro-ophthalmic examination included measurements of visual acuity, contrast sensitivity, and visual field. Quality of life was assessed with the National Eye Institute Visual Function Questionnaire and Neuro-ophthalmic Supplement. MAIN OUTCOME MEASURES: Abnormal vision and health-related quality-of-life scores. RESULTS: Seventy-two percent of the eyes affected with optic neuritis at study entry had visual acuity of > or = 20/20 and 66% of patients had > or = 20/20 acuity in both eyes. On average, visual function was slightly worse among patients with multiple sclerosis (MS) than among with those without MS. As expected, quality-of-life scores were lower when acuity was reduced and when neurologic disability from MS was present. CONCLUSIONS: Long-term visual outcome is favorable for the majority of patients who experience optic neuritis even when MS is present.

Full Text

Duke Authors

Cited Authors

  • Optic Neuritis Study Group,

Published Date

  • June 2008

Published In

Volume / Issue

  • 115 / 6

Start / End Page

  • 1079 - 1082.e5

PubMed ID

  • 17976727

Pubmed Central ID

  • 17976727

Electronic International Standard Serial Number (EISSN)

  • 1549-4713

Digital Object Identifier (DOI)

  • 10.1016/j.ophtha.2007.08.004


  • eng

Conference Location

  • United States