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A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation.

Publication ,  Journal Article
Inohara, T; Piccini, JP; Mahaffey, KW; Kimura, T; Katsumata, Y; Tanimoto, K; Inagawa, K; Ikemura, N; Ueda, I; Fukuda, K; Takatsuki, S; Kohsaka, S
Published in: Am J Cardiol
September 15, 2019

Recently, cluster analysis was used to identify unique clinically relevant phenotypes of atrial fibrillation (AF) in a cohort from the United States (US) and classified clusters according to the presence of comorbid behavioral disorders, those with conduction disorders, or atherosclerotic comorbidities. Whether these phenotypes are consistent in AF cohorts outside the US remains unknown. Thus, we sought to conduct a cluster analysis in a cohort of Japanese AF patients. We conducted a cluster analysis of phenotypic data (46 variables) in an AF patient cohort recruited from 11 Japanese sites participating in the KiCS-AF Registry. Overall, 2,458 AF patients (median [IQR] age, 68.0 [60.0 to 76.0]; 30.3% female; median [IQR] CHA2DS2-Vasc, 2 [1, 3]) were analyzed. Similar to the US cohort, atherosclerotic comorbidities were identified as distinguishing factors to characterize clusters. Distribution of AF type and left atrial (LA) size substantially varied and was the key feature for cluster formation. CHA2DS2-Vasc score also contributed to cluster formation, although behavioral disorders and/or conduction disorders did not readily characterize clusters. Subsequently, the cohort was classified into 3 clusters: (1) Younger paroxysmal AF (n = 1,190); (2) Persistent/permanent AF with LA enlargement (n = 1,143); and (3) Atherosclerotic comorbid AF in elderly patients (N = 125). In conclusion, conventional classifications, such as atherosclerotic risk factors and CHA2DS2-Vasc score contributed to cluster formation in mutually, whereas in nonatherosclerotic clusters, AF type or LA size rather than the presence or absence of behavior risk factors or sinus node dysfunction (tachy-brady syndrome) seemed to contribute to cluster formation in the Japanese cohort.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

September 15, 2019

Volume

124

Issue

6

Start / End Page

871 / 878

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Registries
  • Prospective Studies
  • Outpatients
  • Morbidity
  • Middle Aged
  • Male
  • Japan
  • Humans
 

Citation

APA
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Inohara, T., Piccini, J. P., Mahaffey, K. W., Kimura, T., Katsumata, Y., Tanimoto, K., … Kohsaka, S. (2019). A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation. Am J Cardiol, 124(6), 871–878. https://doi.org/10.1016/j.amjcard.2019.05.071
Inohara, Taku, Jonathan P. Piccini, Kenneth W. Mahaffey, Takehiro Kimura, Yoshinori Katsumata, Kojiro Tanimoto, Kohei Inagawa, et al. “A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation.Am J Cardiol 124, no. 6 (September 15, 2019): 871–78. https://doi.org/10.1016/j.amjcard.2019.05.071.
Inohara T, Piccini JP, Mahaffey KW, Kimura T, Katsumata Y, Tanimoto K, et al. A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation. Am J Cardiol. 2019 Sep 15;124(6):871–8.
Inohara, Taku, et al. “A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation.Am J Cardiol, vol. 124, no. 6, Sept. 2019, pp. 871–78. Pubmed, doi:10.1016/j.amjcard.2019.05.071.
Inohara T, Piccini JP, Mahaffey KW, Kimura T, Katsumata Y, Tanimoto K, Inagawa K, Ikemura N, Ueda I, Fukuda K, Takatsuki S, Kohsaka S. A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation. Am J Cardiol. 2019 Sep 15;124(6):871–878.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

September 15, 2019

Volume

124

Issue

6

Start / End Page

871 / 878

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Registries
  • Prospective Studies
  • Outpatients
  • Morbidity
  • Middle Aged
  • Male
  • Japan
  • Humans