Skip to main content
Journal cover image

Undetectable Hepatitis C Viral Load Is Associated With Improved Outcomes Following Total Joint Arthroplasty.

Publication ,  Journal Article
Novikov, D; Feng, JE; Anoushiravani, AA; Vigdorchik, JM; Lajam, CM; Seyler, TM; Schwarzkopf, R
Published in: J Arthroplasty
December 2019

BACKGROUND: Previous reports establish that infection with hepatitis C virus (HCV) predisposes total joint arthroplasty (TJA) recipients to poor postoperative outcomes. The purpose of the present study is to assess whether variation in HCV VL influences perioperative outcomes following TJA. METHODS: A multicenter retrospective review of all patients diagnosed with HCV who underwent primary TJA between January 2005 and April 2018 was conducted. Patients were stratified into 2 cohorts: (1) patients with an undetectable VL (U-VL) and (2) patients with a detectable VL (D-VL). Kaplan-Meier survivorship analysis was calculated with revision TJA as the end point. Subanalysis on the VL profile was done. RESULTS: A total of 289 TJAs were included (U-VL:118 TJAs; D-VL:171 TJAs). Patients in the D-VL cohort had longer operative times (133.9 vs 109.2 minutes), higher intraoperative blood loss (298.4 vs 219.5 mL), longer inpatient hospital stays (4.0 vs 2.9 days), more postoperative infections (11.7% vs 4.2%), and an increased risk for revision TJA (12.9% vs 5.1%). Kaplan-Meier demonstrated that the U-VL cohort trended toward better survivorship (P = .17). On subanalysis of low and high VL, no difference in outcomes was appreciated. CONCLUSION: TJA recipients with a detectable HCV VL have longer operative times, experience more intraoperative blood loss, have longer hospital length of stay, and are more likely to experience infection and require revision TJA. The blood loss, hospital length of stay, and revision rate findings should be interpreted with caution, however, as there are confounding factors. Our findings suggest that HCV VL is a modifiable risk factor that, can reduce the risk of infection and revision surgery. Additionally, serum HCV VL was not correlated with outcomes.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Arthroplasty

DOI

EISSN

1532-8406

Publication Date

December 2019

Volume

34

Issue

12

Start / End Page

2890 / 2897

Location

United States

Related Subject Headings

  • Viral Load
  • Retrospective Studies
  • Orthopedics
  • Humans
  • Hepatitis C
  • Arthroplasty, Replacement, Knee
  • Arthroplasty, Replacement, Hip
  • 4003 Biomedical engineering
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Novikov, D., Feng, J. E., Anoushiravani, A. A., Vigdorchik, J. M., Lajam, C. M., Seyler, T. M., & Schwarzkopf, R. (2019). Undetectable Hepatitis C Viral Load Is Associated With Improved Outcomes Following Total Joint Arthroplasty. J Arthroplasty, 34(12), 2890–2897. https://doi.org/10.1016/j.arth.2019.06.058
Novikov, David, James E. Feng, Afshin A. Anoushiravani, Jonathan M. Vigdorchik, Claudette M. Lajam, Thorsten M. Seyler, and Ran Schwarzkopf. “Undetectable Hepatitis C Viral Load Is Associated With Improved Outcomes Following Total Joint Arthroplasty.J Arthroplasty 34, no. 12 (December 2019): 2890–97. https://doi.org/10.1016/j.arth.2019.06.058.
Novikov D, Feng JE, Anoushiravani AA, Vigdorchik JM, Lajam CM, Seyler TM, et al. Undetectable Hepatitis C Viral Load Is Associated With Improved Outcomes Following Total Joint Arthroplasty. J Arthroplasty. 2019 Dec;34(12):2890–7.
Novikov, David, et al. “Undetectable Hepatitis C Viral Load Is Associated With Improved Outcomes Following Total Joint Arthroplasty.J Arthroplasty, vol. 34, no. 12, Dec. 2019, pp. 2890–97. Pubmed, doi:10.1016/j.arth.2019.06.058.
Novikov D, Feng JE, Anoushiravani AA, Vigdorchik JM, Lajam CM, Seyler TM, Schwarzkopf R. Undetectable Hepatitis C Viral Load Is Associated With Improved Outcomes Following Total Joint Arthroplasty. J Arthroplasty. 2019 Dec;34(12):2890–2897.
Journal cover image

Published In

J Arthroplasty

DOI

EISSN

1532-8406

Publication Date

December 2019

Volume

34

Issue

12

Start / End Page

2890 / 2897

Location

United States

Related Subject Headings

  • Viral Load
  • Retrospective Studies
  • Orthopedics
  • Humans
  • Hepatitis C
  • Arthroplasty, Replacement, Knee
  • Arthroplasty, Replacement, Hip
  • 4003 Biomedical engineering
  • 3202 Clinical sciences
  • 1103 Clinical Sciences