Nanoantibiotics: a new paradigm for the treatment of surgical infection.

Published

Journal Article (Review)

Infections following orthopedic device implantations often impose a substantial health burden and result in high medical costs. Currently, preventative methods are often employed following an orthopedic implant to reduce risk of infection; however, contamination of the surgical site can still occur. Although antibiotics have demonstrated a substantial reduction in bacterial growth and maintenance, biofilm formation around the implant can often minimize efficacy of the antibiotic. Recently, nanotechnology has garnered significant interest, resulting in the development of several antibiotic delivery strategies that exhibit extended release and increased efficacy. In this review, treatment methods of orthopedic-device-related infections will be discussed and an overview of antimicrobial-based nanotechnologies will be provided. Specifically, nonmetal-, metal- and oxide-based nanotechnologies, incorporating antibacterial strategies, will be discussed.

Full Text

Duke Authors

Cited Authors

  • Fernandez-Moure, JS; Evangelopoulos, M; Colvill, K; Van Eps, JL; Tasciotti, E

Published Date

  • June 2017

Published In

Volume / Issue

  • 12 / 11

Start / End Page

  • 1319 - 1334

PubMed ID

  • 28520517

Pubmed Central ID

  • 28520517

Electronic International Standard Serial Number (EISSN)

  • 1748-6963

Digital Object Identifier (DOI)

  • 10.2217/nnm-2017-0401

Language

  • eng

Conference Location

  • England