Nanometric Considerations in Biofilm Formation.


Journal Article (Review)

Prosthetic contamination and biofilm formation continue to plague implanted materials. With increasing resistance to traditional antibiotic regimens, alternative approaches to preventing bacterial adhesion and biofilm formation have focused on the physiochemical properties of the prosthetics. Roughness, topography, hydrophobicity, porosity, charge, stiffness, and surface area all influence the processes of adhesion and colonization leading to biofilm formation. In this review, we discuss the physiochemical properties of solid and porous prosthetic materials that influence biofilm formation at the nanometric scale.

Full Text

Duke Authors

Cited Authors

  • Fernandez-Moure, JS; Mydlowska, A; Shin, C; Vella, M; Kaplan, LJ

Published Date

  • April 2019

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 167 - 173

PubMed ID

  • 30702383

Pubmed Central ID

  • 30702383

Electronic International Standard Serial Number (EISSN)

  • 1557-8674

Digital Object Identifier (DOI)

  • 10.1089/sur.2018.237


  • eng

Conference Location

  • United States