Biology of aortic aneurysms and dissections.

Journal Article (Journal Article;Review)

The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.

Full Text

Duke Authors

Cited Authors

  • Fernandez-Moure, JS; Vykoukal, D; Davies, MG

Published Date

  • July 2011

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 2 - 7

PubMed ID

  • 21979117

Electronic International Standard Serial Number (EISSN)

  • 1947-6108

Digital Object Identifier (DOI)

  • 10.14797/mdcj-7-3-2


  • eng

Conference Location

  • United States