The role of π-helices in TRP channel gating.

Journal Article (Journal Article;Review)

Transient Receptor Potential (TRP) channels are a large superfamily of polymodal ion channels, which perform important roles in numerous physiological processes. The architecture of their transmembrane (TM) domains closely resembles that of voltage-gated potassium channels (KV). However, recent cryoEM and crystallographic studies of TRP channels have identified π-helices in functionally important regions, and it is increasingly recognized that they utilize a distinct mechanism of gating that relies on α-to-π secondary structure transitions. Here we review our current understanding of the role of π-helices in TRP channel function and their broader impact on different classes of ion channels.

Full Text

Duke Authors

Cited Authors

  • Zubcevic, L; Lee, S-Y

Published Date

  • October 2019

Published In

Volume / Issue

  • 58 /

Start / End Page

  • 314 - 323

PubMed ID

  • 31378426

Pubmed Central ID

  • PMC6778516

Electronic International Standard Serial Number (EISSN)

  • 1879-033X

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England