Pathologic Considerations and Standardization in Mesothelioma Clinical Trials.

Journal Article (Journal Article)

The accurate diagnosis of mesothelioma is critical for the appropriate clinical management of this cancer. Many issues complicate making the diagnosis of mesothelioma including the presence of reactive mesothelial cells in benign pleural effusions, the heterogeneity of mesothelioma histopathology, the relatively high incidence of other epithelial malignancies that metastasize to the pleura, and primary sarcomas that arise within the pleura. Given the rapidly evolving field of molecular profiling and the need for translational correlates in mesothelioma clinical trials, the National Cancer Institute (NCI)-International Association for the Study of Lung Cancer-Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting was convened in March 2017 to develop a consensus on standard pathology guidelines for future NCI-sponsored clinical trials in mesothelioma. This consensus statement covers recommendations for specimen handling, pathologic classification and diagnosis, biobanking, and tissue correlative studies.

Full Text

Duke Authors

Cited Authors

  • Tsao, M-S; Carbone, M; Galateau-Salle, F; Moreira, AL; Nicholson, AG; Roden, AC; Adjei, AA; Aubry, M-C; Fennell, DA; Gomez, D; Harpole, D; Hesdorffer, M; Hirsch, FR; Liu, G; Malik, S; Nowak, A; Peikert, T; Salgia, R; Szlosarek, P; Taioli, E; Yang, H; Tsao, A; Mansfield, AS

Published Date

  • October 2019

Published In

Volume / Issue

  • 14 / 10

Start / End Page

  • 1704 - 1717

PubMed ID

  • 31260832

Electronic International Standard Serial Number (EISSN)

  • 1556-1380

Digital Object Identifier (DOI)

  • 10.1016/j.jtho.2019.06.020

Language

  • eng

Conference Location

  • United States