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Managing cancer-related anaemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: initial evidence from the RESPOND study.

Publication ,  Journal Article
Aapro, M; Van Erps, J; MacDonald, K; Soubeyran, P; Muenzberg, M; Turner, M; Warrinnier, H; Albrecht, T; Abraham, I
Published in: European journal of cancer (Oxford, England : 1990)
January 2009

To model the relationship between scores for practicing in congruence (CSs; 0-10) with EORTC guidelines for erythropoietic proteins (EPs) and haemoglobin (Hb) outcomes observed in the validation study of the RESPOND system.Thirty four patient pairs matched on cancer type and chemotherapy in pre- (retrospective; clinicians not using RESPOND) and post-cohorts (prospective; clinicians using RESPOND) followed over 4 months following EP treatment initiation. CSs quantify the extent that care was guideline-adherent. Linear and logistic regressions controlling for cohort examined Hb outcomes as a function of CSs.A one-point increase in CS was associated with 0.60g/dL increase in Hb at month 4 (R(2)=0.40) and 0.56g/dL increase in Hb change from month 1-4 (R(2)=0.33). Each one-point increase in CS increased the odds of reaching Hb>or=11g/dL by 3.14 (R(2)=0.42) and Hb>or=12g/dL by 2.77 (R(2)=0.45).Guideline-adherent EP treatment may improve Hb outcomes but specifically designed outcomes studies are necessary.

Duke Scholars

Published In

European journal of cancer (Oxford, England : 1990)

DOI

EISSN

1879-0852

ISSN

0959-8049

Publication Date

January 2009

Volume

45

Issue

1

Start / End Page

8 / 11

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Prospective Studies
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Neoplasms
  • Logistic Models
  • Linear Models
  • Humans
  • Hemoglobins
 

Citation

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Aapro, M., Van Erps, J., MacDonald, K., Soubeyran, P., Muenzberg, M., Turner, M., … Abraham, I. (2009). Managing cancer-related anaemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: initial evidence from the RESPOND study. European Journal of Cancer (Oxford, England : 1990), 45(1), 8–11. https://doi.org/10.1016/j.ejca.2008.09.036
Aapro, Matti, Joanna Van Erps, Karen MacDonald, Pierre Soubeyran, Michael Muenzberg, Matthew Turner, Hans Warrinnier, Tara Albrecht, and Ivo Abraham. “Managing cancer-related anaemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: initial evidence from the RESPOND study.European Journal of Cancer (Oxford, England : 1990) 45, no. 1 (January 2009): 8–11. https://doi.org/10.1016/j.ejca.2008.09.036.
Aapro M, Van Erps J, MacDonald K, Soubeyran P, Muenzberg M, Turner M, et al. Managing cancer-related anaemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: initial evidence from the RESPOND study. European journal of cancer (Oxford, England : 1990). 2009 Jan;45(1):8–11.
Aapro, Matti, et al. “Managing cancer-related anaemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: initial evidence from the RESPOND study.European Journal of Cancer (Oxford, England : 1990), vol. 45, no. 1, Jan. 2009, pp. 8–11. Epmc, doi:10.1016/j.ejca.2008.09.036.
Aapro M, Van Erps J, MacDonald K, Soubeyran P, Muenzberg M, Turner M, Warrinnier H, Albrecht T, Abraham I. Managing cancer-related anaemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: initial evidence from the RESPOND study. European journal of cancer (Oxford, England : 1990). 2009 Jan;45(1):8–11.
Journal cover image

Published In

European journal of cancer (Oxford, England : 1990)

DOI

EISSN

1879-0852

ISSN

0959-8049

Publication Date

January 2009

Volume

45

Issue

1

Start / End Page

8 / 11

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Prospective Studies
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Neoplasms
  • Logistic Models
  • Linear Models
  • Humans
  • Hemoglobins