Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.

Journal Article (Journal Article)

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Squamous cell carcinoma is the most common histology in Eastern Europe and Asia, and adenocarcinoma is most common in North America and Western Europe. Surgery is a major component of treatment of locally advanced resectable esophageal and esophagogastric junction (EGJ) cancer, and randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival. Targeted therapies including trastuzumab, ramucirumab, and pembrolizumab have produced encouraging results in the treatment of patients with advanced or metastatic disease. Multidisciplinary team management is essential for all patients with esophageal and EGJ cancers. This selection from the NCCN Guidelines for Esophageal and Esophagogastric Junction Cancers focuses on recommendations for the management of locally advanced and metastatic adenocarcinoma of the esophagus and EGJ.

Full Text

Duke Authors

Cited Authors

  • Ajani, JA; D'Amico, TA; Bentrem, DJ; Chao, J; Corvera, C; Das, P; Denlinger, CS; Enzinger, PC; Fanta, P; Farjah, F; Gerdes, H; Gibson, M; Glasgow, RE; Hayman, JA; Hochwald, S; Hofstetter, WL; Ilson, DH; Jaroszewski, D; Johung, KL; Keswani, RN; Kleinberg, LR; Leong, S; Ly, QP; Matkowskyj, KA; McNamara, M; Mulcahy, MF; Paluri, RK; Park, H; Perry, KA; Pimiento, J; Poultsides, GA; Roses, R; Strong, VE; Wiesner, G; Willett, CG; Wright, CD; McMillian, NR; Pluchino, LA

Published Date

  • July 1, 2019

Published In

Volume / Issue

  • 17 / 7

Start / End Page

  • 855 - 883

PubMed ID

  • 31319389

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2019.0033


  • eng

Conference Location

  • United States