HACEK infective endocarditis: Epidemiology, clinical features, and outcome: A case-control study.


Journal Article

OBJECTIVES:The study aimed to describe the epidemiological, microbiological, and clinical features of a population sample of 17 patients with HACEK infective endocarditis (HACEK-IE) and to compare them with matched control patients with IE caused by viridans group streptococci (VGS-IE). METHODS:Cases of definite (n=14, 82.2%) and possible (n=3, 17.6%) HACEK-IE included in the Infective Endocarditis Hospital Clinic of Barcelona (IE-HCB) database between 1979 and 2016 were identified and described. Furthermore, a retrospective case-control analysis was performed, matching each case to three control subjects with VGS-IE registered in the same database during the same time period. RESULTS:Seventeen out of 1209 IE cases (1.3%, 95% confidence interval 0.69-1.91%) were due to HACEK group organisms. The most frequently isolated HACEK species were Aggregatibacter spp (n=11, 64.7%). Intracardiac vegetations were present in 70.6% of cases. Left heart failure (LHF) was present in 29.4% of cases. Ten patients (58.8%) required in-hospital surgery and none died during hospitalization. In the case-control analysis, there was a trend towards larger vegetations in the HACEK-IE group (median (interquartile range) size 11.5 (10.0-20.0) mm vs. 9.0 (7.0-13.0) mm; p=0.068). Clinical manifestations, echocardiographic findings, LHF rate, systemic emboli, and other complications were all comparable (p>0.05). In-hospital surgery and mortality were similar in the two groups. One-year mortality was lower for HACEK-IE (1/17 vs. to 6/48; p=0.006). CONCLUSIONS:HACEK-IE represented 1.3% of all IE cases. Clinical features and outcomes were comparable to those of the VGS-IE control group. Despite the trend towards a larger vegetation size, the embolic event rate was not higher and the 1-year mortality was significantly lower for HACEK-IE.

Full Text

Cited Authors

  • Ambrosioni, J; Martinez-Garcia, C; Llopis, J; Garcia-de-la-Maria, C; Hernández-Meneses, M; Tellez, A; Falces, C; Almela, M; Vidal, B; Sandoval, E; Fuster, D; Quintana, E; Tolosana, JM; Marco, F; Moreno, A; Miró, JM; Hospital Clinic Infective Endocarditis Investigators,

Published Date

  • November 2018

Published In

Volume / Issue

  • 76 /

Start / End Page

  • 120 - 125

PubMed ID

  • 30153485

Pubmed Central ID

  • 30153485

Electronic International Standard Serial Number (EISSN)

  • 1878-3511

International Standard Serial Number (ISSN)

  • 1201-9712

Digital Object Identifier (DOI)

  • 10.1016/j.ijid.2018.08.013


  • eng