Human immunodeficiency virus-infected liver transplant recipients with incidental hepatocellular carcinoma: A prospective multicenter nationwide cohort study.


Journal Article

There is a lack of data on incidental hepatocellular carcinoma (iHCC) in the setting of liver transplantation (LT) in human immunodeficiency virus (HIV)-infected patients. This study aims to describe the frequency, histopathological characteristics, and outcomes of HIV+ LT recipients with iHCC from a Spanish multicenter cohort in comparison with a matched cohort of LT patients without HIV infection. A total of 15 (6%) out of 271 patients with HIV infection who received LT in Spain from 2002 to 2012 and 38 (5%) out of the 811 HIV- counterparts presented iHCC in liver explants (P = 0.58). Patients with iHCC constitute the present study population. All patients also had hepatitis C virus (HCV)-related cirrhosis. There were no significant differences in histopathological features of iHCC between the 2 groups. Most patients showed a small number and size of tumoral nodules, and few patients had satellite nodules, microvascular invasion, or poorly differentiated tumors. After a median follow-up of 49 months, no patient developed hepatocellular carcinoma (HCC) recurrence after LT. HIV+ LT recipients tended to have lower survival than their HIV- counterparts at 1 (73% versus 92%), 3 (67% versus 84%), and 5 years (50% versus 80%; P = 0.06). There was also a trend to a higher frequency of HCV recurrence as a cause of death in the former (33% versus 10%; P = 0.097). In conclusion, among LT recipients for HCV-related cirrhosis, the incidence and histopathological features of iHCC in HIV+ and HIV- patients were similar. However, post-LT survival was lower in HIV+ patients probably because of a more aggressive HCV recurrence. Liver Transplantation 23 645-651 2017 AASLD.

Full Text

Cited Authors

  • Agüero, F; Forner, A; Valdivieso, A; Blanes, M; Barcena, R; Manzardo, C; Rafecas, A; Castells, L; Abradelo, M; Barrera-Baena, P; González-Diéguez, L; Salcedo, M; Serrano, T; Jiménez-Pérez, M; Herrero, JI; Gastaca, M; Aguilera, V; Fabregat, J; Del Campo, S; Bilbao, I; Romero, CJ; Moreno, A; Rimola, A; Miro, JM; FIPSE Investigators,

Published Date

  • May 2017

Published In

Volume / Issue

  • 23 / 5

Start / End Page

  • 645 - 651

PubMed ID

  • 28188668

Pubmed Central ID

  • 28188668

Electronic International Standard Serial Number (EISSN)

  • 1527-6473

International Standard Serial Number (ISSN)

  • 1527-6465

Digital Object Identifier (DOI)

  • 10.1002/lt.24741


  • eng