Infective endocarditis in patients with an implanted transcatheter aortic valve: Clinical characteristics and outcome of a new entity.


Journal Article (Review)

This study reports one case and review the literature on TAVI-associated endocarditis (TAVIE), to describe its clinical picture and to perform an analysis on prognostic factors.A MEDLINE search from January 2002 to October 2014 revealed 31 cases of TAVIE, including 1 from our hospital. Median age was 81 years (IQR, 78-85), 53% of patients were males and the median age-adjusted Charlson score was 7 (IQR, 5-8). Heart failure was recorded in 42%, embolic events in 19%, and periannular complications in 45%. The most common causative agent was Enterococcus spp (36%). Ten patients (32%) underwent surgery and nine patients died (29%). The prognostic factors for 6-month mortality were heart failure (HR, 9.97 [3.7-24.5]; p = 0.001), periannular complications (HR, 11.82 [3.3-41.3]; p = 0.004), and nonenterococcal/streptococcal etiology (HR, 4.76 [2.1-11.1]; p = 0.03). In patients with heart failure who did not undergo surgery, mortality was 89% (8 out of 9); in those who did undergo surgery, mortality was 0% (p < 0.001).TAVIE is an emerging entity with high mortality. Patients with heart failure who did not undergo surgery had a higher probability of dying. Surgical treatment provided better outcomes even in patients in whom surgery had previously been ruled out.

Full Text

Cited Authors

  • Pericas, JM; Llopis, J; Cervera, C; Sacanella, E; Falces, C; Andrea, R; Garcia de la Maria, C; Ninot, S; Vidal, B; Almela, M; Paré, JC; Sabaté, M; Moreno, A; Marco, F; Mestres, CA; Miro, JM; Hospital Clinic Endocarditis Study Group,

Published Date

  • June 2015

Published In

Volume / Issue

  • 70 / 6

Start / End Page

  • 565 - 576

PubMed ID

  • 25561168

Pubmed Central ID

  • 25561168

Electronic International Standard Serial Number (EISSN)

  • 1532-2742

International Standard Serial Number (ISSN)

  • 0163-4453

Digital Object Identifier (DOI)

  • 10.1016/j.jinf.2014.12.013


  • eng