Genetic variants of innate immune receptors and infections after liver transplantation.


Journal Article (Review)

Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Toll-like receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.

Full Text

Cited Authors

  • Sanclemente, G; Moreno, A; Navasa, M; Lozano, F; Cervera, C

Published Date

  • August 2014

Published In

Volume / Issue

  • 20 / 32

Start / End Page

  • 11116 - 11130

PubMed ID

  • 25170199

Pubmed Central ID

  • 25170199

Electronic International Standard Serial Number (EISSN)

  • 2219-2840

International Standard Serial Number (ISSN)

  • 1007-9327

Digital Object Identifier (DOI)

  • 10.3748/wjg.v20.i32.11116


  • eng