Immunosuppressed patients with pandemic influenza A 2009 (H1N1) virus infection.


Journal Article

The purpose of this paper was to prospectively characterize the clinical manifestations and outcomes of confirmed influenza A 2009 (H1N1) virus infection in immunosuppressed patients with hospital admission and compare them with those of a general population. A multicenter prospective cohort study was carried out. All adult patients admitted to 13 hospitals in Spain with confirmed influenza A 2009 (H1N1) virus infection from June 12, 2009 to November 11, 2009 were included. Risk factors for complicated influenza infection were studied in immunosuppressed patients. Overall, 559 patients were included, of which 56 were immunosuppressed, nine with solid or hematological malignancies, 18 with solid-organ transplant recipients, 13 with corticosteroid therapy, and six with other types of immunosuppression. Clinical findings at diagnosis were similar in both groups. Nineteen immunosuppressed patients had pneumonia (33.9%). Immunosuppressed patients with pandemic influenza had bacterial co-infection more frequently (17.9% vs. 6.4%, p = 0.02), specifically, gram-negative bacilli and Staphylococcus aureus infections. Mortality was higher in immunosuppressed patients (7.1% vs. 1.8%, p < 0.05). The only modifiable risk factor of complicated influenza A 2009 (H1N1) was delayed antiviral therapy. In immunosuppressed patients, influenza A 2009 (H1N1) virus infection has higher mortality than in non-immunosuppressed individuals. Bacterial co-infection is common in complicated cases.

Full Text

Cited Authors

  • Cordero, E; Aydillo, T; Fariñas, MC; Paño-Pardo, JR; Pachón, J; Viasus, D; Riera, M; López-Medrano, F; Payeras, A; Moreno, A; Rodríguez-Baño, J; Oteo, JA; Martínez-Montauti, J; Torre-Cisneros, J; Segura, F; Carratalá, J; Novel Influenza A(H1N1) Study Group of the SpanishNetwork for Research in Infectious Diseases (REIPI),

Published Date

  • April 2012

Published In

Volume / Issue

  • 31 / 4

Start / End Page

  • 547 - 556

PubMed ID

  • 21792558

Pubmed Central ID

  • 21792558

Electronic International Standard Serial Number (EISSN)

  • 1435-4373

International Standard Serial Number (ISSN)

  • 0934-9723

Digital Object Identifier (DOI)

  • 10.1007/s10096-011-1346-3


  • eng