Individualizing salvage regimens: the inhibitory quotient (Ctrough/IC50) as predictor of virological response.


Journal Article

Increased drug levels could overcome resistance and improve the response to a salvage regimen. We evaluate the inhibitory quotient (IQ, Ctrough/protein-binding corrected IC50) as a predictor of virological response in 52 patients included in two dual protease inhibitor (PI)-based salvage regimens. The HIV-RNA level decrease at 12 weeks was greater in patients who achieved an IQ greater than 1. The IQ could be useful to improve the virological response to a dual PI salvage regimen.

Full Text

Cited Authors

  • Casado, JL; Moreno, A; Sabido, R; Martí-Belda, P; Antela, A; Dronda, F; Perez-Elías, MJ; Moreno, S

Published Date

  • January 2003

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 262 - 264

PubMed ID

  • 12545089

Pubmed Central ID

  • 12545089

Electronic International Standard Serial Number (EISSN)

  • 1473-5571

International Standard Serial Number (ISSN)

  • 0269-9370

Digital Object Identifier (DOI)

  • 10.1097/00002030-200301240-00019


  • eng