Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia.


Journal Article

A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total-body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA-identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow-up period. The patient did not develop infectious complications during the procedure. At 35 months of follow-up, his CD4+ T cell count was 1019 cells per microliter. Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.

Full Text

Cited Authors

  • Cervera, C; Fernández-Avilés, F; de la Calle-Martin, O; Bosch, X; Rovira, M; Plana, M; Moreno, A; García, F; Miró, JM; Martínez, A; Gallart, T; Carreras, E; Blade, J; Gatell, JM

Published Date

  • July 2011

Published In

Volume / Issue

  • 87 / 1

Start / End Page

  • 87 - 91

PubMed ID

  • 21447008

Pubmed Central ID

  • 21447008

Electronic International Standard Serial Number (EISSN)

  • 1600-0609

International Standard Serial Number (ISSN)

  • 0902-4441

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0609.2011.01619.x


  • eng