[Human herpesvirus type 6 and type 7 in transplant recipients].


Journal Article (Review)

Recent years have witnessed a growing interest in the role of human herpesvirus (HHV) type 6 and type 7 as emerging pathogens or copathogens in transplant recipients. Both HHV-6 and HHV-7 belong to the beta-herpesvirus family and are closely related to another member of the family, cytomegalovirus. After the primary infection, these viruses remain latent in the human host and can reactivate after transplantation. Various clinical processes such as fever, rash, pneumonitis, encephalitis, hepatitis, and myelosuppression have been described in association with herpesvirus. Moreover, a growing body of evidence suggests that the major impact of HHV-6 and HHV-7 reactivation in transplantation is related to indirect effects, such as their association with cytomegalovirus disease, increased opportunistic infections, and graft dysfunction and rejection. The pathogenesis of HHV-6 and HHV-7 during the post-transplantation period, the methods used for their diagnosis, and the evaluation of antiviral drugs and strategies for their prevention and treatment are now the subject of extensive research.

Full Text

Cited Authors

  • Benito, N; Moreno, A; Pumarola, T; Marcos, MA

Published Date

  • October 1, 2003

Published In

Volume / Issue

  • 21 / 8

Start / End Page

  • 424 - 432

PubMed ID

  • 14525708

Pubmed Central ID

  • 14525708

Electronic International Standard Serial Number (EISSN)

  • 1578-1852

International Standard Serial Number (ISSN)

  • 0213-005X

Digital Object Identifier (DOI)

  • 10.1016/s0213-005x(03)72980-2


  • spa