The use of atazanavir in HIV-infected patients with liver cirrhosis: lack of hepatotoxicity and no significant changes in bilirubin values or model for end-stage liver disease score.


Journal Article

Although atazanavir is widely used in hepatitis C virus (HCV)-HIV-1 patients, little is known about its safety in advanced liver disease. We studied 34 HCV-HIV-1 patients with cirrhosis receiving atazanavir. After 551.2 patient-months of follow-up, there were no cases of serious liver toxicity or cirrhosis decompensation, and only 18.5% discontinued the drug. Despite median bilirubin level at inclusion was 1.5 mg/ml, increases in bilirubin level were mild. Model for end-stage liver disease score (MELD) increased to 1.35 points (95% confidence interval 0.13-2.6), but no patient changed their pretreatment situation after atazanavir introduction. Atazanavir is a well tolerated option in cirrhosis, and significant alterations in bilirubin or MELD were not observed.

Full Text

Cited Authors

  • Rodriguez, JM; Hermida, JM; Casado, JL; Quereda, C; Moreno, A; Dronda, F; Hernandez-Novoa, B; Rodriguez, MA; Perez-Elias, MJ; Moreno, S

Published Date

  • April 2011

Published In

Volume / Issue

  • 25 / 7

Start / End Page

  • 1006 - 1009

PubMed ID

  • 21422988

Pubmed Central ID

  • 21422988

Electronic International Standard Serial Number (EISSN)

  • 1473-5571

International Standard Serial Number (ISSN)

  • 0269-9370

Digital Object Identifier (DOI)

  • 10.1097/qad.0b013e3283466f85


  • eng