Building evidence and measuring clinical outcomes for genomic medicine.

Journal Article (Journal Article;Review)

Human genomic sequencing has potential diagnostic, prognostic, and therapeutic value across a wide breadth of clinical disciplines. One barrier to widespread adoption is the paucity of evidence for improved outcomes in patients who do not already have an indication for more focused testing. In this Series paper, we review clinical outcome studies in genomic medicine and discuss the important features and key challenges to building evidence for next generation sequencing in the context of routine patient care.

Full Text

Duke Authors

Cited Authors

  • Peterson, JF; Roden, DM; Orlando, LA; Ramirez, AH; Mensah, GA; Williams, MS

Published Date

  • August 17, 2019

Published In

Volume / Issue

  • 394 / 10198

Start / End Page

  • 604 - 610

PubMed ID

  • 31395443

Pubmed Central ID

  • PMC6730663

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(19)31278-4


  • eng

Conference Location

  • England