Engineered skeletal muscles for disease modeling and drug discovery.

Journal Article (Review;Journal Article)

Skeletal muscle is the largest organ of human body with several important roles in everyday movement and metabolic homeostasis. The limited ability of small animal models of muscle disease to accurately predict drug efficacy and toxicity in humans has prompted the development in vitro models of human skeletal muscle that fatefully recapitulate cell and tissue level functions and drug responses. We first review methods for development of three-dimensional engineered muscle tissues and organ-on-a-chip microphysiological systems and discuss their potential utility in drug discovery research and development of new regenerative therapies. Furthermore, we describe strategies to increase the functional maturation of engineered muscle, and motivate the importance of incorporating multiple tissue types on the same chip to model organ cross-talk and generate more predictive drug development platforms. Finally, we review the ability of available in vitro systems to model diseases such as type II diabetes, Duchenne muscular dystrophy, Pompe disease, and dysferlinopathy.

Full Text

Duke Authors

Cited Authors

  • Wang, J; Khodabukus, A; Rao, L; Vandusen, K; Abutaleb, N; Bursac, N

Published Date

  • November 2019

Published In

Volume / Issue

  • 221 /

Start / End Page

  • 119416 -

PubMed ID

  • 31419653

Pubmed Central ID

  • PMC7041662

Electronic International Standard Serial Number (EISSN)

  • 1878-5905

International Standard Serial Number (ISSN)

  • 0142-9612

Digital Object Identifier (DOI)

  • 10.1016/j.biomaterials.2019.119416

Language

  • eng