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A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Publication ,  Journal Article
Deelen, J; Evans, DS; Arking, DE; Tesi, N; Nygaard, M; Liu, X; Wojczynski, MK; Biggs, ML; van der Spek, A; Atzmon, G; Ware, EB; Sarnowski, C ...
Published in: Nat Commun
August 14, 2019

Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 14, 2019

Volume

10

Issue

1

Start / End Page

3669

Location

England

Related Subject Headings

  • Longevity
  • Humans
  • Heat-Shock Proteins
  • Genome-Wide Association Study
  • Endoplasmic Reticulum Chaperone BiP
  • Apolipoprotein E4
  • Apolipoprotein E2
 

Citation

APA
Chicago
ICMJE
MLA
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Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., … Murabito, J. M. (2019). A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun, 10(1), 3669. https://doi.org/10.1038/s41467-019-11558-2
Deelen, Joris, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, et al. “A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nat Commun 10, no. 1 (August 14, 2019): 3669. https://doi.org/10.1038/s41467-019-11558-2.
Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 Aug 14;10(1):3669.
Deelen, Joris, et al. “A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nat Commun, vol. 10, no. 1, Aug. 2019, p. 3669. Pubmed, doi:10.1038/s41467-019-11558-2.
Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze J-F, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen L-P, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine J-M, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 Aug 14;10(1):3669.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 14, 2019

Volume

10

Issue

1

Start / End Page

3669

Location

England

Related Subject Headings

  • Longevity
  • Humans
  • Heat-Shock Proteins
  • Genome-Wide Association Study
  • Endoplasmic Reticulum Chaperone BiP
  • Apolipoprotein E4
  • Apolipoprotein E2