ECLS for preemies: the artificial placenta.


Journal Article

The high mortality and morbidity associated with respiratory failure among extremely low gestational age newborns (ELGANs) remains an unsolved problem. A logical strategy to avoid these complications would involve re-creating the intrauterine environment with extracorporeal membrane oxygenation (ECMO) instead of mechanical ventilation. Such a device, termed an artificial placenta, was first researched over 50 years ago. AP models vary, but all incorporate ECMO involving the umbilical vessels, lack of mechanical ventilation, and low partial pressure of oxygen to preserve fetal circulation. Current research has focused on low-volume pumpless arteriovenous circuits as well as pump-driven venovenous circuits.

Full Text

Duke Authors

Cited Authors

  • Bryner, BS; Mychaliska, GB

Published Date

  • March 2014

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • 122 - 129

PubMed ID

  • 24580768

Pubmed Central ID

  • 24580768

Electronic International Standard Serial Number (EISSN)

  • 1558-075X

Digital Object Identifier (DOI)

  • 10.1053/j.semperi.2013.11.007


  • eng

Conference Location

  • United States