The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults.

Journal Article (Journal Article)

OBJECTIVE: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. METHOD: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study ( n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. RESULTS: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. DISCUSSION: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.

Full Text

Duke Authors

Cited Authors

  • Chanti-Ketterl, M; Gamaldo, A; Andel, R; Thorpe, RJ

Published Date

  • June 2018

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 758 - 777

PubMed ID

  • 28553801

Pubmed Central ID

  • PMC5538937

Electronic International Standard Serial Number (EISSN)

  • 1552-6887

Digital Object Identifier (DOI)

  • 10.1177/0898264317690866


  • eng

Conference Location

  • United States