Cholesterol and cognitive performance among community volunteers from the Czech Republic.

Published

Journal Article

BACKGROUND: Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein (HDL), and HDL/LDL ratio in relation to cognitive performance, measured with six well-established cognitive domains and a composite cognitive score (CCS). METHODS: In this cross-sectional study, biomarkers and neuropsychological assessment were available for 141 adults with MMSE scores ≥ 24 (mean age = 69 years, 47% female, mean education = 14.4 years) attending a neuropsychological evaluation. Ordinary least squares regressions were adjusted for age, gender, education, and depressive symptoms in Model 1 and also for apolipoprotein E4 (APOE4) status in Model 2. RESULTS: High-density lipoprotein cholesterol (HDL-C) was associated with better CCS (β = 0.24; p = 0.014). This association was significant among women (β = 0.30; p = 0.026) and not among men (β = 0.20; p = 0.124). HDL-C was also related to attention/working memory (β = 0.24; p = 0.021), again only among women (β = 0.37; p = 0.012) and not men (β = 0.15; p = 0.271). Adjusting for APOE4 yielded significance for high HDL-C and CCS (β = 0.24; p = 0.022). CONCLUSIONS: HDL-C was the main lipoprotein affecting cognitive function, with results somewhat more pronounced among women. Research should investigate the possibility of finding ways to boost HDL-C levels to potentially promote cognitive function.

Full Text

Duke Authors

Cited Authors

  • Chanti-Ketterl, M; Andel, R; Lerch, O; Laczo, J; Hort, J

Published Date

  • December 2015

Published In

Volume / Issue

  • 27 / 12

Start / End Page

  • 2087 - 2095

PubMed ID

  • 25779720

Pubmed Central ID

  • 25779720

Electronic International Standard Serial Number (EISSN)

  • 1741-203X

Digital Object Identifier (DOI)

  • 10.1017/S1041610215000320

Language

  • eng

Conference Location

  • England