Managing the science in the presence of financial conflict of interest.

Journal Article (Journal Article)

We consider the question of why (primarily) and how (secondarily) to perform scientific oversight of research performed by investigators with a financial conflict of interest (COI). One way to frame the trade-off of having investigators with financial COI participate in research is through a decision rule: "Our institution is willing for financially conflicted investigators to participate in research around their intellectual property if (a) the science is likely to be significantly better with their participation (or if other significant benefits accrue); and (b) the COI can be adequately managed". A key component of COI management is the demonstration that the underlying science is sufficiently rigorous and transparent, and in turn, a scientific oversight plan is a key element of that demonstration. Scientific oversight plans should be proactively generated, by individuals (i.e., scientific reviewers) who are independent and expert, and they should assess the rigor and transparency of the research, in a fashion which is fair and efficient. Abbreviations: COI: conflict of interest; SOP: scientific oversight plan.

Full Text

Duke Authors

Cited Authors

  • Samsa, G; Solomon, A

Published Date

  • August 2019

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 397 - 403

PubMed ID

  • 31349765

Electronic International Standard Serial Number (EISSN)

  • 1545-5815

Digital Object Identifier (DOI)

  • 10.1080/08989621.2019.1636652


  • eng

Conference Location

  • United States