Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

Journal Article (Journal Article)

Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (n = 154), (2) sporadic CLL (n = 302), (3) familial MBL (n = 87), (4) unaffected first-degree relatives from CLL/MBL families (n = 263), and (5) reference population (n = 15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (p's < 0.05). However, there were no statistically significant differences in sFLC monoclonal or polyclonal elevations between familial and sporadic CLL cases (p's > 0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (p's < 0.05). This is the first study to demonstrate monoclonal sFLC elevations in CLL cases compared to controls. Monoclonal sFLC levels may provide additional risk information in relatives of CLL probands.

Full Text

Duke Authors

Cited Authors

  • Clay-Gilmour, AI; Rishi, AR; Goldin, LR; Greenberg-Worisek, AJ; Achenbach, SJ; Rabe, KG; Maurer, MJ; Kay, NE; Shanafelt, TD; Call, TG; Brice Weinberg, J; Camp, NJ; Cerhan, JR; Leis, J; Norman, A; Murray, DL; Vincent Rajkumar, S; Caporaso, NE; Landgren, O; McMaster, ML; Slager, SL; Vachon, CM

Published Date

  • August 5, 2019

Published In

Volume / Issue

  • 9 / 8

Start / End Page

  • 59 -

PubMed ID

  • 31383849

Pubmed Central ID

  • PMC6683199

Electronic International Standard Serial Number (EISSN)

  • 2044-5385

Digital Object Identifier (DOI)

  • 10.1038/s41408-019-0220-x


  • eng

Conference Location

  • United States